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Human Body & Health

Why does neurological dysfunction often accompany pellagra, a disease stemming from niacin deficiency?

A)Reduced erythrocyte folate absorption
B)Impaired calcium ion channel synthesis
C)Disrupted NAD+/NADP+ dependent neurotransmitter synthesis
D)Decreased cerebral spinal fluid production

💡 Explanation

Pellagra's neurological symptoms arise because niacin is a precursor to NAD+ and NADP+, crucial coenzymes in neurotransmitter synthesis. Therefore, niacin deficiency impairs these processes, leading to neurological dysfunction, rather than directly affecting folate absorption or CSF production.

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