Why does neuronal damage continue even after initial aggregate formation in Huntington's disease?

💡 Explanation

Neuronal damage persists in Huntington's disease because impaired proteasome function inhibits the Ubiquitin Proteasome System's ability to clear protein aggregates. The proteasome dysfunction leads to accumulation of toxic protein species, therefore exacerbating neuronal damage, rather than resolving it through cellular repair mechanisms.

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