Why does repeated administration of synthetic GnRH agonists, intended to stimulate ovulation, paradoxically inhibit reproductive function?

💡 Explanation

Repeated administration causes downregulation of GnRH receptors on pituitary gonadotrophs, leading to desensitization and decreased LH and FSH release, because the constant stimulation differs from the normal pulsatile GnRH secretion. Therefore, reproductive function is inhibited, rather than stimulated as initially intended with intermittent doses.

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