Why does severe sepsis sometimes lead to acute respiratory distress syndrome (ARDS) in patients?

💡 Explanation

Neutrophils release NETs to trap pathogens during sepsis, but excessive NET formation in the pulmonary capillaries causes endothelial and epithelial damage, leading to ARDS. This occurs because the immune response is overstimulated; therefore, NET accumulation explains ARDS, rather than direct eosinophil or B-cell mediated damage.

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