Why does targeted drug delivery via thermosensitive liposomes fail to induce localized hyperthermia in deep tissue tumors, despite adequate liposome accumulation?

💡 Explanation

Thermosensitive liposomes require a specific temperature threshold for drug release. Insufficient tissue temperature elevation, because of limited heat penetration, prevents effective drug release, therefore the therapy fails, rather than drug loading, leakage, or acoustics causing the problem.

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