A mountain climber ascends rapidly to 14,000 feet. Which consequence will occur in their blood due to the Bohr effect interacting with 2,3-BPG?

💡 Explanation

At high altitude, the Bohr effect causes increased pH due to hyperventilation. The lower pCO2 leads to reduced 2,3-BPG binding to hemoglobin. Because 2,3-BPG stabilizes the deoxy form of hemoglobin, reduced 2,3-BPG results in decreased hemoglobin's oxygen affinity, therefore reduced hemoglobin saturation, rather than increased affinity caused by loss of 2,3-BPG.

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