What causes increased appetite in Prader-Willi syndrome, even after a meal?

💡 Explanation

Prader-Willi syndrome features a dysfunctional hypothalamus, leading to the failure of satiety signals. The mechanism is chronically elevated ghrelin production, which stimulates appetite, even after meals, because the body never gets the signal to stop eating; therefore, elevated ghrelin levels induce constant hunger, rather than satiety signaling via leptin.

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