Why does collagen synthesis decrease in dermal fibroblasts during prolonged exposure to high levels of cortisol, resulting in increased susceptibility to skin damage?

💡 Explanation

Cortisol inhibits the mTOR signaling pathway in fibroblasts, reducing protein synthesis, including collagen. Because collagen provides structural support in the dermis, reduced synthesis weakens the skin. Therefore, the decreased collagen synthesis leads to increased susceptibility to damage, rather than altered melanin, keratinocyte, or sebum production being the primary cause.

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